|
KMID : 0370920110280010077
|
|
Yeungnam Univercity Journal of Medicine
2011 Volume.28 No. 1 p.77 ~ p.83
|
|
|
Treatment of Hemangiopericytoma-Associated Hypoglycemia with Glucocorticoid Therapy
|
|
Park Sung-Woo
Kim Dong-Gun
Kim Myung-Jin
Jang Hyo-Jin
Sohn Se-Hoon
Koh Sung-Ae
Lee Ha-Young
Kim Min-Kyoung
Lee Kyoung-Hee
Hyun Myung-Soo
|
|
|
Abstract
|
|
|
|
Non-islet cell tumor-induced hypoglycemia (NICTH) is associated with mesenchymal tumor types, including hemangiopericytoma, fibrosarcoma, mesothelioma, and neurofibroma, as well as carcinoma of the liver, adrenal glands, and kidneys. Non-islet cell tumors induce hypoglycemia by overproducing an abnormal form of insulin-like growth factor II (IGF II). Complete removal of the tumor or reduction of the tumor mass is a successful therapeutic strategy in cases of NICTH. However, if the tumor re-grows, curative resection is nearly impossible, and hypoglycemia occurs repeatedly. Glucocorticoids are effective in terms of long-term relief from hypoglycemia through promotion of gluconeogenesis in the liver, tumor suppression, production of ’big’-IGF-II, and correction of the attendant biochemical abnormalities involving the growth hormone (GH)-IGF axis. We found that administration of corticosteroid therapy to a patient suffering from NICTH resulted in improvement of hypoglycemia associated symptoms.
|
|
|
KEYWORD
|
|
|
Hemangiopericytoma, Hypoglycemia, Prednisolone
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|